Research Program

Nady Golestaneh, PhD, MSc
Director of Research, Department of Ophthalmology Tenured Associate Professor, Departments of Ophthalmology, Neurology, Biochemistry and Molecular & Cellular Biology

Email: ncg8@georgetown.edu
Office: Med-Dent Bldg, Room NE 203
Lab: Med-Dent Bldg, Room NE 214 – NE220

Education:

Postdoctoral fellowship (2001-2004), NIH, NEI, LMDB

PhD (2000), Sorbonne university, (Pierre et Marie Curie), Biology and Pharmacology of Aging

Master of Science (1995) Sorbonne university, (Pierre et Marie Curie), Biology and Pharmacology of Aging

Bachelor of Science (1994) University of Paris VII, Jussieu, Biochemistry and Cellular Biology

Master of Science (1995) Sorbonne university, (Pierre et Marie Curie), Biology and Pharmacology of Aging

Bachelor of Science (1994) University of Paris VII, Jussieu, Biochemistry and Cellular Biology

Current Research: Dr. Golestaneh’s lab investigates how aging mechanisms affect the cells and induce diseases such as age-related macular degeneration (AMD). Using patient-specific induced pluripotent stem (iPS) cells, Dr. Golestaneh studies the cellular and molecular mechanisms that induce the AMD and develops ways to stop this disease from occurring. Two major research projects include: 1) delineating the role of the of AMPK/SIRT1/PGC-1a on retinal pigment epithelium (RPE) energy metabolisms and functions, (2) investigating the role of mitochondrial dysfunction on AMD and aging.

Publications: https://pubmed.ncbi.nlm.nih.gov/?term=Golestaneh+n

Research Support:

Ongoing:

2019-2024   1 R01 EY028917-01A1, NIH/NEI – PI: Nady Golestaneh: AMPK/SIRT1/PGC-1α, a critical pathway in dry AMD

July 2020-June 2021  Nathan Shock Center – PI: Nady Golestaneh: Investigating a new treatment option for dry AMD

Research Support Completed

2018-2020   Prevention of Blindness – PI: Nady Golestaneh: A targeted therapeutic pathway in age-related macular degeneration

2016-2017    Prevention of Blindness – PI: Nady Golestaneh: A targeted therapeutic pathway in age-related macular degeneration

2014-2016   BrightFocus Foundation – PI: Nady Golestaneh: Autophagy is a critical pathway in AMD

2012-2014   Prevention of Blindness – PI: Nady Golestaneh: Generation of functional RPE from induced pluripotent stem cells

2009-2011 R21 EY019383-01 – PI: Nady Golestaneh: Spermatogonial Stem Cells (SSCs): Prospective for Retinal Degeneration